Crow Medicine opens under the impending threat of West Nile virus. Jane's favourite animals at the Urban Wildlife Rescue Centre (UWRC) are the juvenile crows, mischievous tricksters with blue-black feathers and an appetite for all that sparkles. But the inexplicable deaths of crows in the city, public fear and media frenzy culminate with the UWRC's policy to euthanize all crows admitted in order to protect staff and volunteers from the deadly disease. Torn between her love for the crows and her loyalty to the Centre, Jane sets out on a quest to bring a controversial vaccine back over the Rocky Mountains-in time, she hopes, to save the birds.

Crow Medicine features natural history, facts about the West Nile virus and Native mythology within the context of an action-packed adventure.